10.8 Case Study Conclusion: Wearing His Heart on His Sleeve

Created by CK-12 Foundation/Adapted by Christine Miller

10.8.1 Tattoo
Figure 10.8.1 Let’s hope this couple lasts as long as this tattoo.

Case Study Conclusion: Wearing His Heart on His Sleeve

Are you still wondering whether Ayko, who you read about in the beginning of this chapter, actually got a tattoo of his new girlfriend’s name on his arm? Figure 10.8.1 is your answer! Let’s hope his love for Larissa — and for the artwork — lasts as long as his tattoo. According to a poll conducted for Global TV by Ipsos Reid in 2012, 10% of Canadian and 11% of American adults regret getting a tattoo. Although laser tattoo removal is available, it does not always work fully, can cause pain and scarring, and is expensive and time-consuming. Some people who regret a tattoo opt instead (or additionally) to cover it with another tattoo, see Figure 10.8.2 below.

10.8 Tattoo removal
Figure 10.8.2 This man got his carrot tattoo partially removed using a laser, and then covered it with a new tattoo of flowers.

Why are tattoos essentially permanent? Tattoos are created by inserting a needle containing pigment through the and into the of the skin. The pigment is injected into the dermal layer, creating the design. The pigment can remain in the dermal layer for a person’s lifetime for a few reasons. One, unlike the thinner outer epidermal layer, the dermis is not continually shed and replaced, so the pigment generally stays put. Two, the pigments used in tattooing mainly consist of large particles. When you get a tattoo, the penetration of the skin and insertion of foreign particles causes an immune response in which white blood cells attempt to engulf and remove the pigment. Because most of the pigment particles are so large, however, they cannot be removed from the dermis by the immune cells, and the design remains.

In laser tattoo removal, pulses from a high-intensity laser are applied to the tattoo and absorbed by the pigments. This breaks up the large pigment particles into particles that are small enough to be removed by the immune system. The pigments may then be excreted out of the body, or moved to other areas of the body, such as the lymph nodes. Different wavelengths of laser energy are often required to remove different colours of pigments, because they absorb different wavelengths of light. Generally, blue and black are the easiest colours to remove. Green, red, and yellow tend to be the hardest to remove. It may take as many as six to ten laser treatments — with a few weeks of recovery time in between — to remove a tattoo. Some tattoos can never be completely removed.

Why are mehndi designs (like Ayko’s trial “henna tattoo”) not permanent? Unlike real tattoos, henna paste is applied on the surface of the skin (shown below in Figure 10.8.3), and not injected into the skin with a needle. The dye molecules simply migrate from the paste into the top layer of the epidermis, the .

10.8 Henna Application
Figure 10.8.3 Henna paste being applied to create a mehndi design.

As you have learned, the consists of dead, -filled , which are continually shed and replaced with new cells from the layers below. As a result, mehndi is not permanent. The design is lost as the cells that contain the dye are shed and replaced.

As you read in the beginning of this chapter, mehndi is often applied to the palms of the hands and soles of the feet, which generally results in a darker stain than other areas of the body. This is because the stratum corneum is thicker in these regions, so the dye penetrates through more layers of cells, making the design appear darker. What else is different about the epidermis of the palms and soles? You may recall that these regions are the only place where there is a fifth layer of epidermis — the — making the skin in these areas even thicker and tougher.

Hopefully, Ayko thought carefully about the potential emotional and social implications of getting a tattoo — and learned how difficult they are to remove — before getting a real one. Health and safety should also be of utmost concern to anyone considering getting a tattoo. As you have learned in this chapter, the skin acts as a barrier against dangerous pathogens and substances. When you penetrate the skin using a needle, it can introduce harmful viruses and bacteria directly into the dermis, where the blood vessels are. Tattoo artists and shops need to take precautions to protect their clients against diseases that can be transmitted through blood (such as HIV and hepatitis), as well as bacterial infections. The tattoo artist should wear disposable gloves and a mask, use new and unopened needles and ink tubes, and properly sterilize other equipment. Even if the artist takes all the proper precautions, there is still a chance that the unopened ink could have been contaminated with  during the production process. The shop should be aware of any ink recalls. Anyone getting a tattoo should make sure their artist and shop strictly adhere to all local health and safety regulations.

The risk of disease is not the only risk from tattoos. The pigments in tattoos may contain heavy metals and other potentially toxic substances.  Tattoo parlours are regulated by provincial guidelines in Canada, and these guidelines vary from province to province — but these guidelines are mainly concerned with sterilization of equipment and don’t address anything about pigments.  A recent study published in the scientific journal Nature (Scientific Reports) showed that pigments from tattoos may migrate from a person’s tattoos into their lymph nodes.  Among the substances that make up the tattoo ink that migrated were aluminum, chromium, iron, nickel and copper – all considered “toxic”.

Additionally, people can sometimes have an allergic reaction to the pigments, or develop scarring or granulomas (small bumps of tissue due to an immune response) around the tattoo. Rarely, people can experience temporary swelling or burning of their tattoos when they get scanned in an MRI machine for a medical procedure. Clearly, people should think carefully about the potential health implications before getting a tattoo.

Fortunately, Ayko found a reputable and safe tattoo artist, and is not experiencing any ill effects from his tattoo. He is happy with his tattoo, at least for now. Tattoos — and other kinds of decoration of the — are forms of artistic, personal, and cultural expression that have been used by many cultures over the course of human history. The system that protects us from the elements, helps us maintain , and mediates our interactions with the outside world also happens to be easily modifiable! Whether it is a haircut, makeup, beard style, nail polish, piercing or a tattoo, humans have a variety of ways of altering our integumentary system, which changes our outward appearance and what we communicate to others.

Chapter 10 Summary

In this chapter, you learned about the structures and functions of the organs of the . Specifically, you learned that:

  • The integumentary system consists of the , , and . Functions of the integumentary system include providing a protective covering for the body, sensing the environment, and helping the body maintain .
  • The skin’s main functions include preventing water loss from the body, serving as a barrier to the entry of microorganisms, synthesizing vitamin D, blocking , and helping to regulate body temperature.
  • The skin consists of two distinct layers: a thinner outer layer called the , and a thicker inner layer called the .
    • The epidermis consists mainly of epithelial cells called , which produce . New keratinocytes form at the bottom of the epidermis. They become filled with keratin and die as they move upward toward the surface of the skin, where they form a protective, waterproof layer.
    • The dermis consists mainly of tough  that provide strength and stretch, as well as almost all skin structures, including blood vessels, , , and oil and .
  • Cell types in the epidermis include keratinocytes (which make up 90 per cent of epidermal cells), that produce , that fight pathogens in the skin, and that respond to light touch.
  • In most parts of the body, the epidermis consists of four distinct layers. A fifth layer occurs only in the epidermis of the palms of the hands and soles of the feet.
    1. The innermost layer of the epidermis is the , which contains stem cells that divide to form new keratinocytes.
    2. The next layer is the , which is the thickest layer, and contains Langerhans cells and spiny keratinocytes.
    3. This is followed by the , in which keratinocytes are filling with keratin and beginning to die.
      • The is next, but only on the palms and soles. It consists of translucent dead keratinocytes.
    4. The outermost layer is the , which consists of flat, dead, tightly packed keratinocytes that form a tough, waterproof barrier for the rest of the epidermis.
  • The epidermis protects underlying tissues from physical damage and pathogens. Melanin in the epidermis absorbs and protects underlying tissues from UV light. The epidermis also prevents loss of water from the body and synthesizes vitamin D.
    • is the main pigment that determines the colour of human skin. However, the pigments and also contribute to skin colour, especially in skin with low levels of melanin.
    • The surface of healthy skin normally is covered by vast numbers of representing about one thousand species from 19 phyla. Different areas of the body provide diverse habitats for skin microorganisms. Usually, microorganisms on the skin keep each other in check unless their balance is disturbed.
  • The thicker inner layer of the skin — the — has two layers. The upper has papillae extending upward into the epidermis and loose connective tissues. The lower has denser connective tissues and structures, such as glands and . Glands in the dermis include and , as well as . Hair follicles are structures where hairs originate.
  • Functions of the dermis include cushioning subcutaneous tissues, regulating body temperature, sensing the environment, and excreting wastes. The dense connective tissues of the dermis provide cushioning. The dermis regulates body temperature mainly by sweating and by or . The many tactile sensory receptors in the dermis make it the main organ for the sense of touch. Wastes excreted in sweat include excess water, electrolytes, and certain metabolic wastes.
  • is a filament that grows from a hair follicle in the dermis of the skin. It consists mainly of tightly packed, dead keratinocytes that are filled with keratin. The human body is almost completely covered with hair follicles.
  • Hair helps prevent heat loss from the head and protects its skin from UV light. Hair in the nose filters incoming air, and the eyelashes and eyebrows keep harmful substances out of the eyes. Hair all over the body provides tactile sensory input. The eyebrows also play a role in nonverbal communication.
  • The part of a hair that is within the follicle is the . This is the only living part of a hair. The part of a hair that is visible above the skin surface is the hair shaft. It consists of dead cells.
    • Hair growth begins inside a follicle when stem cells within the follicle divide to produce new keratinocytes.
    • A has three zones: the outermost zone called the , the middle zone called the , and the innermost zone called the .
  • Genetically controlled, visible characteristics of hair include hair colour, hair texture, and the extent of balding in adult males. Melanin ( and/or ) is the pigment that gives hair its colour. Aspects of hair texture include curl pattern, thickness, and consistency.
  • Among mammals, humans are nearly unique in having undergone significant loss of body hair during their evolution, probably because sweat evaporates more quickly from less hairy skin. Curly hair also is thought to have evolved at some point during human evolution, perhaps because it provided better protection from UV light.
  • Hair has social significance for human beings, being an indicator of biological sex, age, and ethnic ancestry. Human hair also has cultural significance. For example, hairstyle may be an indicator of social group membership.
  •  consist of sheets of dead, keratin-filled keratinocytes. The keratin in nails makes them hard but flexible. They help protect the ends of the fingers and toes, enhance the sense of touch in the fingertips, and may be used as tools.
  • A nail has three main parts: the , which is under the epidermis; the , which is the visible part of the nail; and the , which is the distal edge of the nail. Other structures under or around a nail include the , , and .
  • A nail grows from a deep layer of living epidermal tissues, called the nail matrix, at the proximal end of the nail. Stem cells in the nail matrix keep dividing to allow nail growth, forming first the nail root and then the nail plate as the nail continues to grow longer and emerges from the epidermis.
  • Fingernails grow faster than toenails. Actual rates of growth depend on many factors, such as age, sex, and season.
  • The colour of the nail bed can be used to quickly assess oxygen and blood flow in a patient. How the nail plate grows out can reflect recent health problems, such as illness or nutrient deficiency. Nails — and especially toenails — are prone to fungus infections. Nails are more permeable than skin and can absorb several harmful substances, such as herbicides.
  • Skin is a disease in which skin cells grow out of control. It is caused mainly by excessive exposure to UV light, which damages DNA.
  • There are three common types of skin cancer: , , and . Carcinomas are more common and unlikely to metastasize. Melanoma is rare and likely to metastasize. It causes most skin cancer deaths.
  • Besides exposure to UV light, risk factors for skin cancer include having light coloured skin, having many moles, and a family history of skin cancer, among several others.

Now that you have learned about the organs on surface of the body, read the next chapter to travel inside and learn about the skeletal system, which protects and supports us internally, among other functions.

Chapter 10 Review

  1. Describe one way in which the integumentary system works with another organ system to carry out a particular function.
  2. Describe two types of waterproofing used in the integumentary system. Include the types of molecules and where they are located.
  3. Explain why nails enhance touch sensations.
  4. Why do you think light coloured skin is a risk factor for skin cancer?
  5. Describe the similarities between how the epidermis, hair, and nails all grow.
  6. What does the whitish crescent-shaped area at the base of your nails (toward your hands) represent? What is its function?
  7. What is one difference between human hair and the hair of non-human primates?
  8. Describe the relationship between skin and hair.
  9. What kind of skin cancer is a cancer of a type of stem cell?
  10. For the skin and hair, describe one way in which they each protect the body against pathogens.
  11. If sweat glands are in the dermis, how is sweat released to the surface of the body?
  12. Explain why you think that physicians usually insist that patients remove any nail polish before having surgery.
  13. Describe generally how the brain gets touch information from the skin.


Figure 10.8.1

Larissa Tattoo4039922685_46bf0bcfe5_c by Micael Faccio on Flickr is used under a CC BY 2.0 (https://creativecommons.org/licenses/by/2.0/) license.

Figure 10.8.2

Tattoo laser and cover-631211_1280 [photo] by  Herco Roelofs  on Pixabay is used under the Pixabay License (https://pixabay.com/ja/service/license/).

Figure 10.8.3

henna-tattoo-abu-dhabi by MarieFrance on Pixabay is used under the Pixabay License (https://pixabay.com/ja/service/license/).


Global News Staff. (2017, September 15). Health: ‘Toxic’ tattoo ink particles can travel to your lymph nodes: study. Globalnews.ca. https://globalnews.ca/news/3746925/tattoo-ink-safety-lymph-nodes/

Ipsos Reid. (2012). “Two in ten Canadians (22%), Americans (21%)
have a tattoo; One in ten tattooed Canadians (10%), Americans (11%) regret it” [News release]. Ipsos.com. https://www.ipsos.com/sites/default/files/publication/2012-01/5490.pdf

Rideout, K. (2010, July). Comparison of guidelines and regulatory frameworks for personal services establishments. National Collaborating Centre for Environmental Health. https://www.ncceh.ca/sites/default/files/PSE_Guidelines_Comparison_Table_July%202010.pdf

Schreiver, I., Hesse, B., Seim, C. et al. Synchrotron-based ν-XRF mapping and μ-FTIR microscopy enable to look into the fate and effects of tattoo pigments in human skin. Scientific Reports 7,11395. https://doi.org/10.1038/s41598-017-11721-z



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Human Biology Copyright © 2020 by Christine Miller is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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