15.4 Upper Gastrointestinal Tract

Created by CK-12 Foundation/Adapted by Christine Miller

15.4.1 Handstand
Figure 15.4.1 Let’s hope gravity doesn’t work too hard in this case.


Head Stand

Did you ever wonder what would happen if you tried to swallow food while standing on your head like this person in Figure 15.4.1? Many people think that food travels down the gullet from the mouth by the force of gravity. If that were the case, then food you swallowed would stay in your throat while you were standing on your head. In reality, your position doesn’t have much to do with your ability to swallow. Food will travel from your mouth to your stomach whether you are standing upright or upside down. That’s because the tube the food travels through — the — moves the food along via muscular contractions known as . The esophagus is one of several organs that make up the upper gastrointestinal tract.

Organs of the Upper Gastrointestinal Tract

Besides the esophagus, organs of the  include the mouth, pharynx, and stomach. These hollow organs are all connected to form a tube through which food passes during digestion. The only role in digestion played by the pharynx and esophagus is to move food through the GI tract. The mouth and stomach, in contrast, are organs where digestion — or the breakdown of food — also occurs. In both of these organs, food is broken into smaller pieces (), as well as broken down chemically (). It should be noted that the first part of the small intestine (duodenum) is considered in some contexts to be part of the upper GI tract, but that practice is not followed here.


The  is the first organ of the GI tract. Most of the oral cavity is lined with . This tissue produces mucus, which helps moisten, soften, and lubricate food. Underlying the mucous membrane is a thin layer of to which the mucous membrane is only loosely connected. This gives the mucous membrane considerable ability to stretch as you eat food. The roof of the mouth, called the palate, separates the oral cavity from the nasal cavity. The front part is hard, consisting of mucous membrane covering a plate of bone. The back part of the palate is softer and more pliable, consisting of mucous membrane over muscle and connective tissue. The hard surface of the front of the palate allows for pressure needed in chewing and mixing food. The soft, pliable surface of the back of the palate can move to accommodate the passage of food while swallowing. Muscles at either side of the soft palate contract to create the swallowing action.

Several specific structures in the mouth are specialized for digestion. These include salivary glands, tongue, and teeth.

Salivary Glands

Figure 15.4.2 Salivary glands in the mouth include the three major pairs of glands shown here.

The mouth contains three pairs of major , shown in Figure 15.4.2. These three pairs are all  that secrete  into the mouth through ducts.

  1. The largest of the three major pairs of salivary glands are the , which are located on either side of the mouth in front of the ears.
  2. The next largest pair is the , located beneath the lower jaw.
  3. The third pair is the , located underneath the tongue.

In addition to these three pairs of major salivary glands, there are also hundreds of minor salivary glands in the oral mucosa lining the mouth and on the . Along with the major glands, most of the minor glands secrete the digestive enzyme , which begins the chemical digestion of starch and glycogen (polysaccharides). However, the minor salivary glands on the tongue secrete the fat-digesting enzyme , which in the mouth is called lingual lipase (to distinguish it from pancreatic lipase secreted by the pancreas).

Saliva secreted by the salivary glands mainly helps digestion, but it also plays other roles. It helps maintain dental health by cleaning the teeth, and it contains that help protect against infection. By keeping the mouth lubricated, saliva also allows the mouth movements needed for speech.


The is a fleshy, muscular organ that is attached to the floor of the mouth by a band of ligaments that gives it great mobility. This is necessary so the tongue can manipulate food for chewing and swallowing. Movements of the tongue are also necessary for speaking. The upper surface of the tongue is covered with tiny projections called , which contain taste buds. The latter are collections of cells (shown in Figure 15.4.3). These sensory cells sense chemicals in food and send the information to the brain via cranial nerves, thus enabling the sense of taste.

15.4.3 Papillae
Figure 15.4.3 There are several types of papillae located in different areas on the tongue.

There are five basic tastes detected by the chemoreceptor cells in taste buds: saltiness, sourness, bitterness, sweetness, and umami (often described as a meaty taste). Contrary to popular belief, taste buds for the five basic tastes are not located on different parts of the tongue. Why does taste matter? The taste of food helps to stimulate the secretion of saliva from the salivary glands. It also helps us to eat foods that are good for us, instead of rotten or toxic foods. The detection of saltiness, for example, enables the control of salt intake and salt balance in the body. The detection of sourness may help us avoid spoiled foods, which often taste sour due to fermentation by bacteria. The detection of bitterness warns of poisons, because many plants defend themselves with toxins that taste bitter. The detection of sweetness guides us to foods that supply quick energy. The detection of umami may signal protein-rich foods.


The  are complex structures made of a bone-like material called dentin and covered with enamel, which is the hardest tissue in the body. Adults normally have a total of 32 teeth, with 16 in each jaw. The right and left sides of each jaw are mirror images in terms of the numbers and types of teeth they contain. Teeth have different shapes to suit them for different aspects of mastication (chewing). The different types of teeth are illustrated in Figure 15.4.4.

15.4.4 Teeth
Figure 15.4.4 In adults, both sides of each jaw normally have the same numbers of the four types of teeth shown here.
  •  are the sharp, blade-like teeth at the front of the mouth. They are used for cutting or biting off pieces of food. In adults, there are normally four incisors in each jaw, or eight in total.
  •  are the pointed teeth on either side of the incisors. They are used for tearing foods that are tough or stringy. Adults normally have two canines in each jaw, or four altogether.
  •  and  are cuboid teeth with cusps and grooves that are located on the sides and toward the back of the jaws. Premolars are closer to the front of the mouth. Molars are larger and have more cusps than premolars, but both are used for crushing and grinding food. Adults normally have two premolars and three molars on each side of each jaw, for a total of eight premolars and twelve molars.


The tube-like (see Figure 15.4.5 below) plays a dual role as an organ of both respiration and digestion. As part of the , it conducts air between the and . As part of the , it allows swallowed food to pass from the oral cavity to the . Anything swallowed has priority over inhaled air when passing through the pharynx. During swallowing, the backward motion of the tongue causes a flap of elastic cartilage — called the — to close over the opening to the larynx. This prevents food or drink from entering the larynx.

Figure 15.4.5 The tongue moves backward during swallowing to cause the epiglottis to cover the opening to the larynx. As a result, food passes from the pharynx to the esophagus — and not into the larynx.


The  (shown in Figure 15.4.6) is a muscular tube through which food is pushed from the pharynx to the stomach. The esophagus passes through an opening in the (the large breathing muscle that separates the abdomen from the thorax) before reaching the . In adults, the esophagus averages about 25 cm (about 9.8 inches) in length, depending on a person’s height. The inner lining of the esophagus consists of mucous membrane, which provides a smooth, slippery surface for the passage of food. The cells of this membrane are constantly being replaced as they are worn away from the frequent passage of food over them.

15.4.6 Esophagus
Figure 15.4.6 The esophagus moves food by peristalsis from the pharynx to the stomach. Note, this x-ray of a swallow shows a fraction of the ingested liquid being trapped in an atypical diverticulum of the esophagus.

When food is not being swallowed, the esophagus is closed at both ends by upper and lower esophageal sphincters.  are rings of muscle that can contract to close off openings between structures. The upper esophageal sphincter is triggered to relax and open by the act of swallowing, allowing a bolus of food to enter the esophagus from the pharynx. Then, the esophageal sphincter closes again to prevent food from moving back into the pharynx from the esophagus.

Once in the esophagus, the food travels down to the stomach, pushed along by the rhythmic contraction and relaxation of muscles (). The lower esophageal sphincter is located at the junction between the esophagus and the stomach. This sphincter opens when the bolus reaches it, allowing the food to enter the stomach. The sphincter normally remains closed at other times to prevent the contents of the stomach from entering the esophagus. Failure of this sphincter to remain completely closed can lead to heartburn. If it happens chronically, it can lead to gastroesophageal reflux disease (GERD), in which the mucous membrane of the esophagus may become damaged by the highly acidic contents of the stomach.

See the video below to see how the parts of the upper GI tract work together to carry out swallowing:

Swallowing, uploaded by Alejandra Cork, 2012.


The  is a J-shaped organ (shown in Figure 15.4.7) that is joined to the esophagus at its upper end, and to the first part of the () at its lower end. When the stomach is empty of food, it normally has a volume of about 75 millilitres, but it can expand to hold up to about a litre of food. Waves of muscle contractions (peristalsis) passing through the muscular walls of the stomach cause the food inside to be mixed and churned. The wall of the stomach has an extra layer of muscle tissue not found in other organs of the GI tract that helps it squeeze and mix the food. These movements of the stomach wall contribute greatly to mechanical digestion by breaking the food into much smaller pieces. The churning also helps mix the food with stomach secretions that aid in its chemical digestion.

Figure 15.4.7 The stomach is connected at the top to the esophagus and at the bottom to the duodenum of the small intestine. The pylorus, or pyloric sphincter, controls emptying of the stomach into the small intestine. The outer surface of the stomach is covered with fibrous connective tissue. There are three layers of muscle in the stomach wall. Each layer runs in a different direction: circular, longitudinal and oblique.

Secretions of the stomach include gastric acid, which consists mainly of hydrochloric acid (HCl). This makes the stomach contents highly acidic, which is necessary so that the enzyme — also secreted by the stomach — can begin the digestion of . is secreted by the lining of stomach to provide a slimy protective coating against the otherwise damaging effects of gastric acid. The fat-digesting enzyme is secreted in small amounts in the stomach, but very little fat digestion occurs there.

By the time food has been in the stomach for about an hour, it has become the thick, semi-liquid . When the is ready to receive chyme, a sphincter between the stomach and duodenum — called the pyloric sphincter — opens to allow the chyme to enter the small intestine for further digestion and absorption.

Feature: Reliable Sources

The ongoing epidemic of obesity in the wealthier nations of the world, including Canada, has led to the development of several different bariatric surgeries that modify the stomach to help obese patients reduce their food intake and lose weight. Go online to learn more about bariatric surgery. Find sources you judge to be reliable that answer the following questions:

  1. Who qualifies for bariatric surgery?
  2. Describe the bariatric surgeries commonly called stomach stapling, lap band, and gastric sleeve. How does each type of surgery modify the stomach? In terms of weight loss, how effective is each type?
  3. What are the major potential risks of bariatric surgery?
  4. Besides weight loss, what other benefits have been shown to result from bariatric surgery?

15.4 Summary

  • Organs of the include the mouth, pharynx, esophagus, and stomach.
  • The is the first organ of the GI tract. It has several structures that are specialized for digestion, including , , and . Both and of carbohydrates and fats begin in the mouth.
  • The and move food from the mouth to the stomach, but are not involved in the process of digestion or absorption. Food moves through the esophagus by .
  • Mechanical and chemical digestion continue in the stomach. Acid and digestive enzymes secreted by the stomach start the chemical digestion of proteins. The stomach turns masticated food into a semi-fluid mixture called .

15.4 Review Questions

  1. Identify structures in the mouth that are specialized for digestion.
  2. Describe digestion in the mouth.
  3. What general role do the pharynx and esophagus play in the digestion of food?
  4. How does food travel through the esophagus?
  5. Describe digestion in the stomach.
  6. Describe the differences between how air and food normally move past the pharynx.
  7. Name two structures in the mouth that contribute to mechanical digestion.
  8. What structure normally keeps stomach contents from backing up into the esophagus?
  9. Thirty minutes after you eat a meal, where is most of your food located? Explain your answer.
  10. What are two roles of mucus in the upper GI tract?

15.4 Explore More

What causes cavities? – Mel Rosenberg, TED-Ed, 2016.

How does alcohol make you drunk? – Judy Grisel, TED-Ed, 2020.

Gastric Bypass Surgery: One Patient’s Journey – Mayo Clinic, 2014.

Here’s What Happens In Your Body When You Swallow Gum | The Human Body, Tech Insider, 2018.


Figure 15.4.1

Handstand, Pender Island, B.C. [photo] by Jasper Garratt on Unsplash is used under the Unsplash License (https://unsplash.com/license).

Figure 15.4.2

Blausen_0780_SalivaryGlands by BruceBlaus on Wikimedia Commons is used under a CC BY 3.0 (https://creativecommons.org/licenses/by/3.0) license.

Figure 15.4.3

1402_The_Tongue by OpenStax on Wikimedia Commons is used under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0) license.

Figure 15.4.4

1024px-3D_Medical_Animation_Still_Showing_Types_of_Teeth by http://www.scientificanimations.com on Wikimedia Commons is used under a CC BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0) license.

Figure 15.4.5

Illu01_head_neck by Arcadian from NCI/ SEER Training Modules on Wikimedia Common is in the public domain (https://en.wikipedia.org/wiki/public_domain).

Figure 15.4.6

ZenkerSchraeg by Bernd Brägelmann Braegel on Wikimedia Commons is used under a CC BY 3.0  (https://creativecommons.org/licenses/by/3.0) license.  (Courtesy of Dr. Martin Steinhoff. It is not known whether there is a possibly necessary approval from the patient.)

Figure 15.4.7

Anatomy stomach – white by www.medicalgraphics.de from MedicalGraphics is used under a  CC BY-ND 4.0 (https://creativecommons.org/licenses/by-nd/4.0/) license.


Alejandra Cork. (2012). Swallowing. YouTube. https://www.youtube.com/watch?v=pNcV6yAfq-g&t=4s

Betts, J. G., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., DeSaix, P. (2016, May 27). Figure 14.3 The tongue [digital image]. In Anatomy and Physiology (Section 14.1). OpenStax. https://openstax.org/books/anatomy-and-physiology/pages/14-1-sensory-perception

Blausen.com Staff. (2014). Medical gallery of Blausen Medical 2014. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436.

Mayo Clinic. (2014, August 26). Gastric bypass surgery: One patient’s journey – Mayo Clinic. https://www.youtube.com/watch?v=twJBEypJDfU&feature=youtu.be

Mayo Clinic Staff. (n.d.). Gastroesophageal reflux disease (GERD) [online article]. MayoClinic.org. https://www.mayoclinic.org/diseases-conditions/gerd/symptoms-causes/syc-20361940

Tech Insider. (2018, March 20). Here’s what happens in your body when you swallow gum | The human body. YouTube. https://www.youtube.com/watch?v=u_1sVri3b2w&feature=youtu.be

TED-Ed. (2020, April 9). How does alcohol make you drunk? – Judy Grisel. YouTube. https://www.youtube.com/watch?v=gCrmFbgT37I&feature=youtu.be

TED-Ed. (2016, October 17). What causes cavities? – Mel Rosenberg. YouTube. https://www.youtube.com/watch?v=zGoBFU1q4g0&feature=youtu.be



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Human Biology by Christine Miller is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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